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What is Actidiane?

Actidiane is a clinical study conducted in various hospitals and sports centers across France and Belgium.

The objective of this study is to determine the efficiency of a high-intensity physical activity program on kidney function in patients with type 2 diabetes and a rapid decline in renal function.

Type 2 diabetes is a chronic disease characterized by insulin resistance and a decrease in insulin production by the pancreas. This pathology causes a number of complications including renal diseases (kidney diseases). Decline in renal function has been identified as an important factor in the diagnosis of renal or cardiovascular disease. Measurement of glomerular filtration rate ( eGFR ) allows a good diagnosis of renal and cardiovascular function in diabetic patients.

This study will therefore focus on comparing the effect of a structured High Intensity Physical Activity Program (HIPA) versus a recommended standard physical program on renal function in patients with type 2 diabetes and a decline in kidney function over a period of 1 to 2 years.

It was shown in a previous study that the HIPA program could have beneficial effects on blood pressure and cardiovascular risk.

To participate in the study, patients must be at least 45 years old and diagnosed with type 2 diabetes and with a high risk of nephropathy (rapid decline of renal function).

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What is diabetes ?

Also called fatty or maturitydiabetes, type 2 diabetes is a disease characterized by chronic excess of blood sugar (hyperglycemia). It occurs more often in obese or overweight people, generally older than 50 years. It affects more than a million and a half people in France, and continues to grow. It accounts for about 85% of all diabetes, and affects as many men as women.

The risk factors for type 2 diabetes are multiple:

The risk factors for type 2 diabetes are multiple:

  • Genetics and heredity: a hereditary factor is very often found ('many members of the family have diabetes'). In addition, some populations are particularly affected which confirms its genetic origin
  • Overweight and obesity: 60% to 90% of patients with diabetes are overweight
  • Physical inactivity
  • Some drugs.

Chronic hyperglycemia is most often asymptomatic, that is, it is not felt. If diabetes is very unbalanced, symptoms may appear :
  • Thirst
  • Want to urinate very often (it is the polyuro-polydipsic syndrome).
  • Asthenia
  • Weight loss
  • Repeated urinary infections
  • Fungal infections
  • Furunculosis
Finally, diabetes can be revealed by the signs of complications: visual disturbances, leg pain or cramps, impotence, cardiac or vascular pathology, coma ...

For more information on diabetes, click on this link : Définition INSERM

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